The CMIRC was established in January 2009 by Prof. Jameel Inal, with initial funding from the Royal Society and NHS. Together with external collaborators/associate members, researchers with backgrounds in Immunology, Infectious disease (virology/parasitology) Cell Biology, Structural Biology and Molecular Biology and Genetics, now aim to focus their combined research efforts in Molecular Biology and Immunology to help further our understanding of the immunology of infection and cancer progression and to apply this knowledge for possible future therapies.

The Centre has two main interests:

1. Membrane Vesicles (MVs) and exosomes released from cells, with the following applications:

(i) role of MVs in cell-cell communication, applied to haematopoietic cell differentiation in leukaemia and tumour progression and metastasis.

(ii) role of MVs (&/or exosomes) in host-pathogen (parasite, bacteria and viral) interaction and manipulation thereof to inhibit infection.

(iii) Genetics of MV release.

2. Regulation of the complement system, with two major applications:

(i) how infectious agents (intracellular protozoan parasite Trypanosoma cruzi and extracellular parasite Giardia intestinalis) attempt to overcome this branch of immune defence, in particular the lectin pathway of complement activation, to establish infection.

(ii) how to therapeutically inhibit complement in autoimmune disease (where complement is misdirected against self). Our main tool at the moment is the complement-inhibiting synthetic peptide CRIT-H17, whose structure we have modelled.

Friday, 6 July 2012

Microvesiculation and disease

13—14 September 2012
London Metropolitan University, UK

A Biochemical Society Focused Meeting

Meeting background

Microvesiculation and disease, 2012, will bring together researchers in biomedicine to discuss the burgeoning field of microvesicles and exosomes. The specific emphasis will be the role they play in cancer, development and infectious and autoimmune disease, but will also look to new therapies targeting the microvesicle and exosome communication system.
  • Autoimmune disease and microvesicles
  • Infectious disease and microvesicles
  • Genetics and microvesicles
  • Cancer and microvesicles
Reviews by the speakers, based on their presentations at this major international meeting, will be published exclusively in Biochemical Society Transactions (Volume 41, part 1).
Abstract deadline: 12 July 2012.
Abstract submission is now open. 

Earlybird registration deadline: 13 August 2012.
Registration is now open.

Oral communication slots are available at this

meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication.

Student Bursaries are available for this meeting.

Approved by the Society of Biology for the purpose of CPD, this event may be counted as 36 CPD credits.

Sponsored by: